Boreal’s linked molecule patent portfolio includes alternate chemistries for high-accuracy sequencing, targeted ligation of unknown gene fusions and other applications.


  • Duplex sequencing without the use of molecular barcodes or tags for ultra-low error detection (Pro-Seq)
  • Targeted ligation to desired sequences of interest for applications such as:
  • Detection of gene fusions with unknown partners
  • Singe-stranded DNA & RNA library prep and target capture
  • Amplification-free target capture for single molecule sequencing


Learn more about Pro-Seq in PLOS ONE